Background and Objectives: After distinguishing the role of Helicobacter pylori in
gastritis and peptic ulcer, some hypothesis were brought up about the probable
interference of this germ in dyspepsia. This study was done in order to determine the
prevalence of Helicobacter pylori infection in persons conflicted with dyspepsia, attended
in 5thAzar hospital in Gorgan during 8 months (from 2001 Mar 21 2001 Nov 22).
Materials and Methods: In this research, 270 patients with diagnosis of dyspepsia were
endoscopied based on clinical examinations and paraclinic studies and after rulling out of
erusive gastrodeodenitis and peptic ulcer, two biopsy samples were taken from antrum.
Then, the samples were put in urea rapid test environment media. The required time for
positive response was 15 minutes but to be completely sure about it, urea environment
media consisted of biopsy samples were maintained for 2 hours. Any colour changes
during this time were considered as positive response.
Results: Among 270 patients conflicted with dyspepsia 136 patients were male and 134
were female with age average of 40.9% y/o. the patients with Helicobater pylori infection
were 139 (51.5%) and the ones without infection were 131(48.5%), and age averages
were 44.4 y/o and 37.3 y/o, respectively. The prevalences of dyspepsia subgroups were as
follows:
Ulcer like 53.7%, reflux like 31.1%, non specific 9.6%, and dis motility like 5.6%, and
the prevalence of infection among dyspepsia subgroups wre as follws:
Ulcer like 62.02%, reflux like 40.47%, non specific 46.15% and dis motility like 20%.
Other risk factors in these patients were as follows: cigarette smoking 25.6%, NSAID
16.3% and alcohol drinking 4.1%.
Conclusion: This study suggests that Helicobacter pylori infection can have a role in
formation of dyspepsia.